BindingDB logo
myBDB logout

null

SMILES: COc1cc(ccn1)-c1nc2cc(F)cc(F)c2c(N2CC3(CCOCC3)c3ncc(cc23)N2CCOCC2)c1C

InChI Key: InChIKey=ZGLJFGHARPUBIA-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124762   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM124762
PNG
(US8765940, 1'-(5,7-difluoro-2-(2-methoxy-4-pyr...)
Show SMILES COc1cc(ccn1)-c1nc2cc(F)cc(F)c2c(N2CC3(CCOCC3)c3ncc(cc23)N2CCOCC2)c1C
Show InChI InChI=1S/C31H31F2N5O3/c1-19-28(20-3-6-34-26(13-20)39-2)36-24-15-21(32)14-23(33)27(24)29(19)38-18-31(4-9-40-10-5-31)30-25(38)16-22(17-35-30)37-7-11-41-12-8-37/h3,6,13-17H,4-5,7-12,18H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
 6.89n/an/an/an/an/an/a7.0n/a



Amgen Inc.

US Patent


Assay Description
A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...

US Patent US8765940 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7G94
More data for this
Ligand-Target Pair