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SMILES: COC(=O)N1CCN(CC1)c1nc2cc(F)cc(F)c2c(N2CC3(CCOCC3)c3ncc(cc23)N2CCOCC2)c1C

InChI Key: InChIKey=LFLLVUCSJDNBFY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124777   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM124777
PNG
(US8765940, methyl 4-(5,7-difluoro-3-methyl-4-(6...)
Show SMILES COC(=O)N1CCN(CC1)c1nc2cc(F)cc(F)c2c(N2CC3(CCOCC3)c3ncc(cc23)N2CCOCC2)c1C
Show InChI InChI=1S/C31H36F2N6O4/c1-20-27(26-23(33)15-21(32)16-24(26)35-29(20)37-5-7-38(8-6-37)30(40)41-2)39-19-31(3-11-42-12-4-31)28-25(39)17-22(18-34-28)36-9-13-43-14-10-36/h15-18H,3-14,19H2,1-2H3
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MMDB

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Similars
US Patent
 3.11n/an/an/an/an/an/a7.0n/a



Amgen Inc.

US Patent


Assay Description
A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...

US Patent US8765940 (2014)


BindingDB Entry DOI: 10.7270/Q2WW7G94
More data for this
Ligand-Target Pair