null
SMILES: Cc1[nH]nc2ccc(cc12)C1C([N+]#[C-])C(C)=NC2=C1C(=O)OC2
InChI Key: InChIKey=ZPJBJFQOAIBECC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM124886 (US8759341, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Bayer Intellectual Property GmbH US Patent | Assay Description For the assay, 50 mL of a 100-fold concentrated solution of the test compound in DMSO is pipetted into a black low-volume 384-well microtiter plate (... | US Patent US8759341 (2014) BindingDB Entry DOI: 10.7270/Q2HQ3XMW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM124886 (US8759341, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Bayer Intellectual Property GmbH US Patent | Assay Description Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge... | US Patent US8759341 (2014) BindingDB Entry DOI: 10.7270/Q2HQ3XMW | |||||||||||
More data for this Ligand-Target Pair |