BDBM125219 US8772481, 5

SMILES: Cc1ccc(cc1-c1nncc2nc(Oc3ccc(F)cc3F)ccc12)C(N)=O

InChI Key: InChIKey=DTAXEFSZDMLROF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 125219   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM125219 (US8772481, 5) Show SMILES Cc1ccc(cc1-c1nncc2nc(Oc3ccc(F)cc3F)ccc12)C(N)=O Show InChI InChI=1S/C21H14F2N4O2/c1-11-2-3-12(21(24)28)8-15(11)20-14-5-7-19(26-17(14)10-25-27-20)29-18-6-4-13(22)9-16(18)23/h2-10H,1H3,(H2,24,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	n/a
Amgen Inc. US Patent					Assay Description Kinase reaction buffer for p38alpha HTRF assays consists of 50 mM Tris-pH 7.5, 5 mM MgCl2, 0.1 mg/mL BSA, 100 uM Na3VO4 and 0.5 mM DTT. HTRF Detectio...				US Patent US8772481 (2014) BindingDB Entry DOI: 10.7270/Q2ZP44T4
					More data for this Ligand-Target Pair