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SMILES: CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCC(F)(F)F)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=USIMWRYQHAXOHD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 125571   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM125571
PNG
(US8772316, 54)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCC(F)(F)F)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H28F3N3O4/c1-5-6-22-19-13-24(37-4)23(36-3)12-18(19)20(26(34)33-22)11-16-9-15-10-17(35-2)7-8-21(15)32-25(16)31-14-27(28,29)30/h7-10,12-13H,5-6,11,14H2,1-4H3,(H,31,32)(H,33,34)
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Similars
US Patent
n/an/a 23n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...

US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair