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SMILES: CCCc1[nH]c(=O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=CJVDWJPLBJARQN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 125601   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM125601
PNG
(US8772316, 84)
Show SMILES CCCc1[nH]c(=O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O4/c1-5-6-22-19-13-24(31-4)23(30-3)12-18(19)20(25(28)27-22)10-15-9-16-11-17(29-2)7-8-21(16)26-14-15/h7-9,11-14H,5-6,10H2,1-4H3,(H,27,28)
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Similars
US Patent
n/an/a 1.60n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...

US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair