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SMILES: CCc1[nH]c(=O)c(Cc2cc3cc(OCC4CC4)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12

InChI Key: InChIKey=RGFZDLIMJXHJAH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 125604   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM125604
PNG
(US8772316, 87)
Show SMILES CCc1[nH]c(=O)c(Cc2cc3cc(OCC4CC4)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C31H36N4O5/c1-5-26-24-16-29(39-4)28(38-3)15-23(24)25(31(37)35-26)14-21-12-20-13-22(40-17-19-6-7-19)8-9-27(20)34-30(21)33-11-10-32-18(2)36/h8-9,12-13,15-16,19H,5-7,10-11,14,17H2,1-4H3,(H,32,36)(H,33,34)(H,35,37)
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Similars
US Patent
n/an/a 3.90n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...

US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair