BDBM125925 US8772478, 14

SMILES: Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCOCC2)C(=O)NO)c2ccccc2n1

InChI Key: InChIKey=KHOXRRQYROMPSZ-QHCPKHFHSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 125925   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 33 (Homo sapiens (Human))	BDBM125925 (US8772478, 14) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCOCC2)C(=O)NO)c2ccccc2n1 Show InChI InChI=1S/C24H28N4O6S/c1-17-14-18(21-4-2-3-5-22(21)26-17)16-34-19-6-8-20(9-7-19)35(31,32)25-15-23(24(29)27-30)28-10-12-33-13-11-28/h2-9,14,23,25,30H,10-13,15-16H2,1H3,(H,27,29)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	7.4	n/a
Galderma Research & Development US Patent					Assay Description The products are solubilized in DMSO at a concentration of 10 mM. A serial 3-fold dilution over 10 points is carried out so as to have a concentratio...				US Patent US8772478 (2014) BindingDB Entry DOI: 10.7270/Q29Z93JW
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM125925 (US8772478, 14) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCOCC2)C(=O)NO)c2ccccc2n1 Show InChI InChI=1S/C24H28N4O6S/c1-17-14-18(21-4-2-3-5-22(21)26-17)16-34-19-6-8-20(9-7-19)35(31,32)25-15-23(24(29)27-30)28-10-12-33-13-11-28/h2-9,14,23,25,30H,10-13,15-16H2,1H3,(H,27,29)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.03E+3	n/a	n/a	n/a	n/a	7.4	n/a
Galderma Research & Development US Patent					Assay Description The products are solubilized in DMSO at a concentration of 10 mM. A serial 3-fold dilution over 10 points is carried out so as to have a concentratio...				US Patent US8772478 (2014) BindingDB Entry DOI: 10.7270/Q29Z93JW
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 33 (Homo sapiens (Human))	BDBM125925 (US8772478, 14) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCOCC2)C(=O)NO)c2ccccc2n1 Show InChI InChI=1S/C24H28N4O6S/c1-17-14-18(21-4-2-3-5-22(21)26-17)16-34-19-6-8-20(9-7-19)35(31,32)25-15-23(24(29)27-30)28-10-12-33-13-11-28/h2-9,14,23,25,30H,10-13,15-16H2,1H3,(H,27,29)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	7.4	n/a
Galderma Research & Development US Patent					Assay Description The products are solubilized in DMSO at a concentration of 10 mM. A serial 3-fold dilution over 10 points is carried out so as to have a concentratio...				US Patent US8772478 (2014) BindingDB Entry DOI: 10.7270/Q29Z93JW
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) (Homo sapiens (Human))	BDBM125925 (US8772478, 14) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCOCC2)C(=O)NO)c2ccccc2n1 Show InChI InChI=1S/C24H28N4O6S/c1-17-14-18(21-4-2-3-5-22(21)26-17)16-34-19-6-8-20(9-7-19)35(31,32)25-15-23(24(29)27-30)28-10-12-33-13-11-28/h2-9,14,23,25,30H,10-13,15-16H2,1H3,(H,27,29)/t23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
Galderma Research & Development US Patent					Assay Description The products are solubilized in DMSO at a concentration of 10 mM. A serial 3-fold dilution over 10 points is carried out so as to have a concentratio...				US Patent US8772478 (2014) BindingDB Entry DOI: 10.7270/Q29Z93JW
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human))	BDBM125925 (US8772478, 14) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCOCC2)C(=O)NO)c2ccccc2n1 Show InChI InChI=1S/C24H28N4O6S/c1-17-14-18(21-4-2-3-5-22(21)26-17)16-34-19-6-8-20(9-7-19)35(31,32)25-15-23(24(29)27-30)28-10-12-33-13-11-28/h2-9,14,23,25,30H,10-13,15-16H2,1H3,(H,27,29)/t23-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
Galderma Research & Development US Patent					Assay Description The products are solubilized in DMSO at a concentration of 10 mM. A serial 3-fold dilution over 10 points is carried out so as to have a concentratio...				US Patent US8772478 (2014) BindingDB Entry DOI: 10.7270/Q29Z93JW
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM125925 (US8772478, 14) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)NC[C@H](N2CCOCC2)C(=O)NO)c2ccccc2n1 Show InChI InChI=1S/C24H28N4O6S/c1-17-14-18(21-4-2-3-5-22(21)26-17)16-34-19-6-8-20(9-7-19)35(31,32)25-15-23(24(29)27-30)28-10-12-33-13-11-28/h2-9,14,23,25,30H,10-13,15-16H2,1H3,(H,27,29)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
Galderma Research & Development US Patent					Assay Description The products are solubilized in DMSO at a concentration of 10 mM. A serial 3-fold dilution over 10 points is carried out so as to have a concentratio...				US Patent US8772478 (2014) BindingDB Entry DOI: 10.7270/Q29Z93JW
					More data for this Ligand-Target Pair