null
SMILES: COc1ccccc1C(=O)c1cnc(NC2CCNCC2)nc1N
InChI Key: InChIKey=ZJMXSDPJDCXSAG-UHFFFAOYSA-N
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human)) | BDBM12605 (2,4-Diamino-5-ketopyrimidine 23 | 5-[(2-methoxyphe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 481 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. | Assay Description Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv... | J Med Chem 49: 6549-60 (2006) Article DOI: 10.1021/jm0606138 BindingDB Entry DOI: 10.7270/Q2QR4VB2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM12605 (2,4-Diamino-5-ketopyrimidine 23 | 5-[(2-methoxyphe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 5.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. | Assay Description Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv... | J Med Chem 49: 6549-60 (2006) Article DOI: 10.1021/jm0606138 BindingDB Entry DOI: 10.7270/Q2QR4VB2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human)) | BDBM12605 (2,4-Diamino-5-ketopyrimidine 23 | 5-[(2-methoxyphe...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 6.27E+3 | -7.38 | n/a | n/a | n/a | n/a | n/a | 7.0 | 37 |
Hoffmann-La Roche Inc. | Assay Description Enzymes were assayed with retinoblastoma substrate in 384-well plates containing diluted test compounds. Final ATP concentration was 3x the respectiv... | J Med Chem 49: 6549-60 (2006) Article DOI: 10.1021/jm0606138 BindingDB Entry DOI: 10.7270/Q2QR4VB2 | |||||||||||
More data for this Ligand-Target Pair |