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BDBM126188 US8778957, 184

SMILES: CC(C)[C@H]1CN(C)CCN1Cc1ccc2cc3CC4(Cc3cc2n1)C(C)C(=O)NC4=O

InChI Key: InChIKey=JFQVNOLOYOZRPO-PMBLGMBLSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126188   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcitonin gene-related peptide (CGRP alpha)


(Homo sapiens (Human))
BDBM126188
PNG
(US8778957, 184)
Show SMILES CC(C)[C@H]1CN(C)CCN1Cc1ccc2cc3CC4(Cc3cc2n1)C(C)C(=O)NC4=O |r|
Show InChI InChI=1S/C25H32N4O2/c1-15(2)22-14-28(4)7-8-29(22)13-20-6-5-17-9-18-11-25(12-19(18)10-21(17)26-20)16(3)23(30)27-24(25)31/h5-6,9-10,15-16,22H,7-8,11-14H2,1-4H3,(H,27,30,31)/t16?,22-,25?/m1/s1
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PC cid
PC sid
UniChem
US Patent
1.70E+3 -7.87n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Cells expressing recombinant human CL receptor/RAMP1 were washed with PBS and harvested in harvest buffer containing 50 mM HEPES, 1 mM EDTA and Compl...


US Patent US8778957 (2014)


BindingDB Entry DOI: 10.7270/Q29022G8
More data for this
Ligand-Target Pair