BDBM12627 (2S,5S)-1-L-leucyl-5-methylpyrrolidine-2-carbonitrile::(2S,5S)-1-[(2S)-2-amino-4-methylpentanoyl]-5-methylpyrrolidine-2-carbonitrile::C5-substituted pyrrolidine 15

SMILES: CC(C)C[C@H](N)C(=O)N1[C@@H](C)CC[C@H]1C#N

InChI Key: InChIKey=XAPWGIWPMYCPRT-DCAQKATOSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12627   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM12627 ((2S,5S)-1-L-leucyl-5-methylpyrrolidine-2-carbonitr...) Show SMILES CC(C)C[C@H](N)C(=O)N1[C@@H](C)CC[C@H]1C#N |r| Show InChI InChI=1S/C12H21N3O/c1-8(2)6-11(14)12(16)15-9(3)4-5-10(15)7-13/h8-11H,4-6,14H2,1-3H3/t9-,10-,11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	49	-9.86	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...				J Med Chem 49: 6416-20 (2006) Article DOI: 10.1021/jm060777o BindingDB Entry DOI: 10.7270/Q2M043M1
					More data for this Ligand-Target Pair