BDBM12633 (2S,5S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethynylpyrrolidine-2-carbonitrile::C5-substituted pyrrolidine 21

SMILES: N[C@H](C1CCCCC1)C(=O)N1[C@@H](CC[C@H]1C#N)C#C

InChI Key: InChIKey=FRGISDJQXAKTDV-HZSPNIEDSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 12633   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM12633 ((2S,5S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethy...) Show SMILES N[C@H](C1CCCCC1)C(=O)N1[C@@H](CC[C@H]1C#N)C#C |r| Show InChI InChI=1S/C15H21N3O/c1-2-12-8-9-13(10-16)18(12)15(19)14(17)11-6-4-3-5-7-11/h1,11-14H,3-9,17H2/t12-,13+,14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	>-6.10	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...				J Med Chem 49: 6416-20 (2006) Article DOI: 10.1021/jm060777o BindingDB Entry DOI: 10.7270/Q2M043M1
					More data for this Ligand-Target Pair