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BDBM126503 US8778951, 313

SMILES: N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(F)CCOCC2)n1

InChI Key: InChIKey=RHYTUGYKLVRVAV-WKILWMFISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 126503   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-T1


(Homo sapiens (Human))		BDBM126503
PNG
(US8778951, 313)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(F)CCOCC2)n1 |r,wU:4.7,wD:1.0,(5.33,1.93,;4,2.69,;4,4.23,;2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;,5,;-1.33,4.23,;-1.33,2.69,;-2.67,1.93,;-4,2.69,;-5.33,1.93,;-4,4.23,;-2.67,5,;-2.67,.38,;-4,-.38,;-4,-1.93,;-2.67,-2.69,;-1.33,-1.93,;,-2.69,;1.33,-1.93,;2.67,-2.69,;2.67,-1.15,;2.67,-4.23,;4,-5,;5.33,-4.23,;5.33,-2.69,;4,-1.92,;-1.33,-.38,)|
Show InChI InChI=1S/C22H29ClFN5O/c23-18-13-26-21(28-16-6-4-15(25)5-7-16)12-17(18)19-2-1-3-20(29-19)27-14-22(24)8-10-30-11-9-22/h1-3,12-13,15-16H,4-11,14,25H2,(H,26,28)(H,27,29)/t15-,16-
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Similars
US Patent
n/an/a 0.00100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...

US Patent US8778951 (2014)


BindingDB Entry DOI: 10.7270/Q25B014T
More data for this
Ligand-Target Pair