BDBM126693 US8778970, 5-1::US8778970, 5-12::US8778970, 5-13
SMILES: O=S(=O)c1ccccc1.COCCOc1cc(CC2CCN(CCc3ccc4OCCC(O)c4c3)CC2)ccc1Br
InChI Key: InChIKey=KHBCZXZGHJUMOW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.60 | -11.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description [3H] citalopram binding was assayed according to the method of Owens et al. [Owens M. J. et al., J. Pharm. Exp. Ther., 283, 1305-1322 (1997)]. Specif... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 6.30 | -11.2 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description [3H] citalopram binding was assayed according to the method of Owens et al. [Owens M. J. et al., J. Pharm. Exp. Ther., 283, 1305-1322 (1997)]. Specif... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 8.20 | -11.0 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description [3H] citalopram binding was assayed according to the method of Owens et al. [Owens M. J. et al., J. Pharm. Exp. Ther., 283, 1305-1322 (1997)]. Specif... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 12 | -10.8 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description The experiment was carried out according to the method of Yabuuchi et al. [Yabuuchi K. et al., Biogenic Amines, 18, 319-328 (2004)]. 50 ul of [3H] 8-... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 22 | -10.4 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description The experiment was carried out according to the method of Yabuuchi et al. [Yabuuchi K. et al., Biogenic Amines, 18, 319-328 (2004)]. 50 ul of [3H] 8-... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 184 | -9.18 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description The experiment was carried out according to the method of Yabuuchi et al. [Yabuuchi K. et al., Biogenic Amines, 18, 319-328 (2004)]. 50 ul of [3H] 8-... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description Procedure: 1. A 10 mM solution of a test drug in DMSO was serially diluted with DMSO at four 5-fold dilutions to prepare 10, 2, 0.4 and 0.08 mM DM... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description Procedure: 1. A 10 mM solution of a test drug in DMSO was serially diluted with DMSO at four 5-fold dilutions to prepare 10, 2, 0.4 and 0.08 mM DM... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM126693 (US8778970, 5-1 | US8778970, 5-12 | US8778970, 5-13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd US Patent | Assay Description Procedure: 1. A 10 mM solution of a test drug in DMSO was serially diluted with DMSO at four 5-fold dilutions to prepare 10, 2, 0.4 and 0.08 mM DM... | US Patent US8778970 (2014) BindingDB Entry DOI: 10.7270/Q2N878GH | |||||||||||
More data for this Ligand-Target Pair |