BDBM12715 2-{4-[1-(4-methoxyphenyl)-4-methyl-7-oxo-3-(trifluoromethyl)-1H,6H,7H-pyrazolo[3,4-d]pyridazin-6-yl]phenyl}benzene-1-sulfonamide::pyrazolo[3,4-d]pyridazinone 32
SMILES: COc1ccc(cc1)-n1nc(c2c(C)nn(-c3ccc(cc3)-c3ccccc3S(N)(=O)=O)c(=O)c12)C(F)(F)F
InChI Key: InChIKey=MWWMMKSYCBBFRB-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor X (Homo sapiens (Human)) | BDBM12715 (2-{4-[1-(4-methoxyphenyl)-4-methyl-7-oxo-3-(triflu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80 | -11.5 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Company | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | Bioorg Med Chem Lett 16: 3755-60 (2006) Article DOI: 10.1016/j.bmcl.2006.04.044 BindingDB Entry DOI: 10.7270/Q2319T41 | |||||||||||
More data for this Ligand-Target Pair |