BDBM127432 US8791131, 206

SMILES: COCCN1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O

InChI Key: InChIKey=CZBHWKXRLDJYIN-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127432   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM127432 (US8791131, 206) Show SMILES COCCN1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O Show InChI InChI=1S/C25H31N7O2/c1-29(2)22-8-5-17(15-27-22)19-6-7-20-23(28-19)24-21(16-26-20)30(3)25(33)32(24)18-9-11-31(12-10-18)13-14-34-4/h5-8,15-16,18H,9-14H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.802	-12.4	n/a	n/a	n/a	n/a	n/a	7.4	25
Pfizer Inc. US Patent					Assay Description Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...				US Patent US8791131 (2014) BindingDB Entry DOI: 10.7270/Q23B5XV8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM127432 (US8791131, 206) Show SMILES COCCN1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O Show InChI InChI=1S/C25H31N7O2/c1-29(2)22-8-5-17(15-27-22)19-6-7-20-23(28-19)24-21(16-26-20)30(3)25(33)32(24)18-9-11-31(12-10-18)13-14-34-4/h5-8,15-16,18H,9-14H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8.09	-11.0	n/a	n/a	n/a	n/a	n/a	7.5	25
Pfizer Inc. US Patent					Assay Description Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...				US Patent US8791131 (2014) BindingDB Entry DOI: 10.7270/Q23B5XV8
					More data for this Ligand-Target Pair