BindingDB PrimarySearch

BDBM12787 3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)propanamide::5-amidinoindole 21::amidinoindole 22

SMILES: NC(=N)c1ccc2[nH]cc(C(Cc3ccc(N)cc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1

InChI Key: InChIKey=SAOAIXOGVSHQNA-UHFFFAOYSA-N

Data: 4 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 12787
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM12787 (3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)ph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4	-11.3	n/a	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Pharmaceutical Research Institute					Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...				Bioorg Med Chem Lett 15: 29-35 (2005) Article DOI: 10.1016/j.bmcl.2004.10.045 BindingDB Entry DOI: 10.7270/Q2K072H3
Bristol-Myers Squibb Pharmaceutical Research Institute					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM12787 (3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)ph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4	-11.3	n/a	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...				Bioorg Med Chem Lett 14: 5269-73 (2004) Article DOI: 10.1016/j.bmcl.2004.08.037 BindingDB Entry DOI: 10.7270/Q2PR7T6P
Bristol-Myers Squibb Company					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM12787 (3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)ph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute					Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...				Bioorg Med Chem Lett 15: 29-35 (2005) Article DOI: 10.1016/j.bmcl.2004.10.045 BindingDB Entry DOI: 10.7270/Q2K072H3
Bristol-Myers Squibb Pharmaceutical Research Institute					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM12787 (3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)ph...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...				Bioorg Med Chem Lett 14: 5269-73 (2004) Article DOI: 10.1016/j.bmcl.2004.08.037 BindingDB Entry DOI: 10.7270/Q2PR7T6P
Bristol-Myers Squibb Company					More data for this Ligand-Target Pair