BDBM127883 US10017516, Compound 6::US9682983, 6
SMILES: C1N[C@H]2C[C@@H]1N(C2)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
InChI Key: InChIKey=JDAFKLSYNCTYHC-FPOVZHCZSA-N
Data: 12 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 383 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.22E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (ALK1) (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 383 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair |