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BDBM127895 US8791130, 25

SMILES: CNc1nc(Nc2ccc(cc2OC)-c2ccnn2C)ncc1C(F)(F)F

InChI Key: InChIKey=KVYXOOIQSIRKGI-UHFFFAOYSA-N

Data: 1 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127895   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM127895
PNG
(US8791130, 25)
Show SMILES CNc1nc(Nc2ccc(cc2OC)-c2ccnn2C)ncc1C(F)(F)F
Show InChI InChI=1S/C17H17F3N6O/c1-21-15-11(17(18,19)20)9-22-16(25-15)24-12-5-4-10(8-14(12)27-3)13-6-7-23-26(13)2/h4-9H,1-3H3,(H2,21,22,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


Citation and Details
More data for this
Ligand-Target Pair