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SMILES: Cc1cnc(C)c2nc(CCc3cn4Cc5cc(F)ccc5-c4n3)nn12

InChI Key: InChIKey=GGBDFAFNTZNZLQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127925   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM127925 (US8796304, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...) Show SMILES Cc1cnc(C)c2nc(CCc3cn4Cc5cc(F)ccc5-c4n3)nn12 Show InChI InChI=1S/C19H17FN6/c1-11-8-21-12(2)18-23-17(24-26(11)18)6-4-15-10-25-9-13-7-14(20)3-5-16(13)19(25)22-15/h3,5,7-8,10H,4,6,9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...				US Patent US9062060 (2015) BindingDB Entry DOI: 10.7270/Q25719S0
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM127925 (US8796304, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...) Show SMILES Cc1cnc(C)c2nc(CCc3cn4Cc5cc(F)ccc5-c4n3)nn12 Show InChI InChI=1S/C19H17FN6/c1-11-8-21-12(2)18-23-17(24-26(11)18)6-4-15-10-25-9-13-7-14(20)3-5-16(13)19(25)22-15/h3,5,7-8,10H,4,6,9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8796304 (2014) BindingDB Entry DOI: 10.7270/Q2FN14WW
					More data for this Ligand-Target Pair