BDBM127941 US8796310, 1D

SMILES: Cc1cc(Nc2cc(ccn2)N2CCNCC2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O

InChI Key: InChIKey=PANGETTYTUWTFZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127941   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM127941 (US8796310, 1D) Show SMILES Cc1cc(Nc2cc(ccn2)N2CCNCC2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O Show InChI InChI=1S/C29H30N6O3S/c1-18-13-23(33-26(14-18)34-25-16-21(6-8-31-25)35-11-9-30-10-12-35)24-17-32-28(39-24)29(38)7-2-3-19-15-20(27(36)37)4-5-22(19)29/h4-6,8,13-17,30,38H,2-3,7,9-12H2,1H3,(H,36,37)(H,31,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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