BDBM128013 US8796310, 1A

SMILES: Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O

InChI Key: InChIKey=IPCWPMKGLFZOGM-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128013   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM128013 (US8796310, 1A) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O Show InChI InChI=1S/C26H22F2N4O3S/c1-14-9-19(31-22(10-14)32-21-12-16(23(27)28)6-8-29-21)20-13-30-25(36-20)26(35)7-2-3-15-11-17(24(33)34)4-5-18(15)26/h4-6,8-13,23,35H,2-3,7H2,1H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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