BDBM128263 US8796296, 18

SMILES: CCN1Cc2c(ccc(Nc3ncc(c(NC)n3)C(F)(F)F)c2OC)C1=O

InChI Key: InChIKey=ZONZCYNPXUSQCJ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM128263 (US8796296, 18) Show SMILES CCN1Cc2c(ccc(Nc3ncc(c(NC)n3)C(F)(F)F)c2OC)C1=O Show InChI InChI=1S/C17H18F3N5O2/c1-4-25-8-10-9(15(25)26)5-6-12(13(10)27-3)23-16-22-7-11(17(18,19)20)14(21-2)24-16/h5-7H,4,8H2,1-3H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US8796296 (2014) BindingDB Entry DOI: 10.7270/Q28W3C0R
					More data for this Ligand-Target Pair