BDBM128277 US8796296, 33

SMILES: CNc1nc(Nc2cc3n(C)cc(C(=O)N4C[C@@H]5C[C@H]4CO5)c3cc2Cl)ncc1C(F)(F)F

InChI Key: InChIKey=HUHWITKPBBDVQO-QWRGUYRKSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM128277 (US8796296, 33) Show SMILES CNc1nc(Nc2cc3n(C)cc(C(=O)N4C[C@@H]5C[C@H]4CO5)c3cc2Cl)ncc1C(F)(F)F |r,TLB:13:15:21.20:18| Show InChI InChI=1S/C21H20ClF3N6O2/c1-26-18-14(21(23,24)25)6-27-20(29-18)28-16-5-17-12(4-15(16)22)13(8-30(17)2)19(32)31-7-11-3-10(31)9-33-11/h4-6,8,10-11H,3,7,9H2,1-2H3,(H2,26,27,28,29)/t10-,11-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US8796296 (2014) BindingDB Entry DOI: 10.7270/Q28W3C0R
					More data for this Ligand-Target Pair