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SMILES: CN(C)Cc1ccc(cc1)-c1ccc(cc1)-n1c(C[C@@H]2CCN(C2)C(=O)C2CC2)n[nH]c1=O

InChI Key: InChIKey=GQCSMNUCGMSULW-IBGZPJMESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128364   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fatty acid synthase


(Homo sapiens (Human))		BDBM128364
PNG
(US8802864, 95)
Show SMILES CN(C)Cc1ccc(cc1)-c1ccc(cc1)-n1c(C[C@@H]2CCN(C2)C(=O)C2CC2)n[nH]c1=O |r|
Show InChI InChI=1S/C26H31N5O2/c1-29(2)16-18-3-5-20(6-4-18)21-9-11-23(12-10-21)31-24(27-28-26(31)33)15-19-13-14-30(17-19)25(32)22-7-8-22/h3-6,9-12,19,22H,7-8,13-17H2,1-2H3,(H,28,33)/t19-/m0/s1
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Similars
US Patent
n/an/a 200n/an/an/an/a7.0n/a



GlaxoSmithKline LLC

US Patent


Assay Description
Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...

US Patent US8802864 (2014)


BindingDB Entry DOI: 10.7270/Q2N58K26
More data for this
Ligand-Target Pair