BDBM1286 3-Aminopyridin-2(1H)-one analogue 6::5-ethyl-6-methyl-3-[(quinolin-3-ylmethyl)amino]-1,2-dihydropyridin-2-one::CHEMBL125510

SMILES: CCc1cc(NCc2cnc3ccccc3c2)c(=O)[nH]c1C

InChI Key: InChIKey=RJDHCISUIBFLAH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 1286   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM1286 (3-Aminopyridin-2(1H)-one analogue 6 | 5-ethyl-6-me...) Show SMILES CCc1cc(NCc2cnc3ccccc3c2)c(=O)[nH]c1C Show InChI InChI=1S/C18H19N3O/c1-3-14-9-17(18(22)21-12(14)2)20-11-13-8-15-6-4-5-7-16(15)19-10-13/h4-10,20H,3,11H2,1-2H3,(H,21,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	339	n/a	n/a	n/a	n/a	n/a	n/a
Organon Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV-1 reverse transcriptase (HIV-1 RT)				J Med Chem 39: 4065-72 (1996) Article DOI: 10.1021/jm960058h BindingDB Entry DOI: 10.7270/Q2Z039F0
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1286 (3-Aminopyridin-2(1H)-one analogue 6 | 5-ethyl-6-me...) Show SMILES CCc1cc(NCc2cnc3ccccc3c2)c(=O)[nH]c1C Show InChI InChI=1S/C18H19N3O/c1-3-14-9-17(18(22)21-12(14)2)20-11-13-8-15-6-4-5-7-16(15)19-10-13/h4-10,20H,3,11H2,1-2H3,(H,21,22)	PDB MMDB B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	335	n/a	n/a	n/a	n/a	8.2	n/a
Merck Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 35: 3792-802 (1992) Article DOI: 10.1021/jm00099a007 BindingDB Entry DOI: 10.7270/Q2GH9G3P
					More data for this Ligand-Target Pair