BDBM128646 US8796244, 235

SMILES: CCNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ncc(c(N)n1)C(F)(F)F

InChI Key: InChIKey=YUBNVBSTUSZFME-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 128646   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM128646 (US8796244, 235) Show SMILES CCNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ncc(c(N)n1)C(F)(F)F Show InChI InChI=1S/C21H18F3N7O/c1-2-26-20(32)29-14-5-3-4-12(8-14)16-11-27-17-9-13(6-7-31(16)17)19-28-10-15(18(25)30-19)21(22,23)24/h3-11H,2H2,1H3,(H2,25,28,30)(H2,26,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	8.0	25
Astex Therapeutics Ltd US Patent					Assay Description VEGFR2 (from Upstate), prepared at 2x final concentration, was incubated with test compounds, biotinylated Flt3 substrate (biotin-VASSDNEYFYVDF) (Cel...				US Patent US8796244 (2014) BindingDB Entry DOI: 10.7270/Q20C4TFP
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM128646 (US8796244, 235) Show SMILES CCNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ncc(c(N)n1)C(F)(F)F Show InChI InChI=1S/C21H18F3N7O/c1-2-26-20(32)29-14-5-3-4-12(8-14)16-11-27-17-9-13(6-7-31(16)17)19-28-10-15(18(25)30-19)21(22,23)24/h3-11H,2H2,1H3,(H2,25,28,30)(H2,26,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.880	n/a	n/a	n/a	n/a	8.0	25
Astex Therapeutics Ltd US Patent					Assay Description Enzymes (from Upstate) were prepared at 2× final concentration in 1× kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...				US Patent US8796244 (2014) BindingDB Entry DOI: 10.7270/Q20C4TFP
					More data for this Ligand-Target Pair