BDBM1287 3-Aminopyridin-2(1H)-one analogue 7::3-[(1,3-benzothiazol-2-ylmethyl)amino]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one::CHEMBL431274::Pyridinone deriv. 4

SMILES: CCc1cc(NCc2nc3ccccc3s2)c(=O)[nH]c1C

InChI Key: InChIKey=YYFIAMJITQWHCZ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 1287   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1287 (3-Aminopyridin-2(1H)-one analogue 7 | 3-[(1,3-benz...) Show SMILES CCc1cc(NCc2nc3ccccc3s2)c(=O)[nH]c1C Show InChI InChI=1S/C16H17N3OS/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)	PDB MMDB B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	8.2	n/a
Merck Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 35: 3792-802 (1992) Article DOI: 10.1021/jm00099a007 BindingDB Entry DOI: 10.7270/Q2GH9G3P
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM1287 (3-Aminopyridin-2(1H)-one analogue 7 | 3-[(1,3-benz...) Show SMILES CCc1cc(NCc2nc3ccccc3s2)c(=O)[nH]c1C Show InChI InChI=1S/C16H17N3OS/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
Organon Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV-1 reverse transcriptase (HIV-1 RT)				J Med Chem 39: 4065-72 (1996) Article DOI: 10.1021/jm960058h BindingDB Entry DOI: 10.7270/Q2Z039F0
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1287 (3-Aminopyridin-2(1H)-one analogue 7 | 3-[(1,3-benz...) Show SMILES CCc1cc(NCc2nc3ccccc3s2)c(=O)[nH]c1C Show InChI InChI=1S/C16H17N3OS/c1-3-11-8-13(16(20)18-10(11)2)17-9-15-19-12-6-4-5-7-14(12)21-15/h4-8,17H,3,9H2,1-2H3,(H,18,20)	PDB MMDB B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	8.2	n/a
Merck Sharp and Dohme Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 34: 2922-5 (1991) Article DOI: 10.1021/jm00113a036 BindingDB Entry DOI: 10.7270/Q2WM1BK1
					More data for this Ligand-Target Pair