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BDBM130034 US8815926, 316

SMILES: COc1ncc(-c2nc3C(=O)N([C@H](c3n2[C@H](C)CO)c2ccc(Cl)cc2)c2cccc(Cl)c2F)c(OC)n1

InChI Key: InChIKey=ZIVYGCBNCGFBLY-ASSNKEHSSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130034   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM130034
PNG
(US8815926, 316)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@H](c3n2[C@H](C)CO)c2ccc(Cl)cc2)c2cccc(Cl)c2F)c(OC)n1 |r|
Show InChI InChI=1S/C26H22Cl2FN5O4/c1-13(12-35)33-22-20(31-23(33)16-11-30-26(38-3)32-24(16)37-2)25(36)34(18-6-4-5-17(28)19(18)29)21(22)14-7-9-15(27)10-8-14/h4-11,13,21,35H,12H2,1-3H3/t13-,21+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.107n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...


US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair