BDBM130068 US8815901, 20

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12

InChI Key: InChIKey=OIOCAEZDOFSWBM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130068   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM130068 (US8815901, 20) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ncc(CN3CCN(C)CC3)[nH]2)c2nccnc12 |(10.91,-2.76,;9.37,-2.76,;8.6,-1.43,;9.37,-.1,;8.6,1.24,;9.37,2.57,;8.6,3.91,;7.06,1.24,;6.29,2.57,;6.29,-.1,;7.06,-1.43,;6.29,-2.76,;4.75,-.1,;3.98,1.24,;2.44,1.24,;1.67,-.1,;.13,-.1,;-.64,1.24,;-.64,-1.43,;-2.18,-1.43,;-3.09,-.18,;-4.55,-.66,;-4.55,-2.2,;-5.8,-3.1,;-7.13,-2.33,;-7.13,-.79,;-8.46,-.02,;-9.8,-.79,;-11.13,-.02,;-9.8,-2.33,;-8.46,-3.1,;-3.09,-2.67,;2.44,-1.43,;1.67,-2.76,;2.44,-4.1,;3.98,-4.1,;4.75,-2.76,;3.98,-1.43,)| Show InChI InChI=1S/C26H27Cl2N7O3/c1-34-8-10-35(11-9-34)14-15-13-31-26(32-15)33-25(36)17-5-4-16(23-24(17)30-7-6-29-23)20-21(27)18(37-2)12-19(38-3)22(20)28/h4-7,12-13H,8-11,14H2,1-3H3,(H2,31,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair