BDBM130081 US8815901, 155

SMILES: COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12

InChI Key: InChIKey=HKNCLTAHXPLYKK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130081   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM130081 (US8815901, 155) Show SMILES COc1cc(OC)c(Cl)c(c1F)-c1ccc(C(=O)Nc2ncc(CN3CCNC(=O)C3)[nH]2)c2nccnc12 |(8.7,3.96,;9.47,2.62,;8.7,1.29,;9.47,-.04,;8.7,-1.38,;9.47,-2.71,;11.01,-2.71,;7.16,-1.38,;6.39,-2.71,;6.39,-.04,;7.16,1.29,;6.39,2.62,;4.85,-.04,;4.08,1.29,;2.54,1.29,;1.77,-.04,;.23,-.04,;-.54,1.29,;-.54,-1.38,;-2.08,-1.38,;-2.98,-.13,;-4.45,-.61,;-4.45,-2.15,;-5.78,-2.92,;-7.11,-2.15,;-7.11,-.61,;-8.45,.16,;-9.78,-.61,;-9.78,-2.15,;-11.12,-2.92,;-8.45,-2.92,;-2.98,-2.62,;2.54,-1.38,;1.77,-2.71,;2.54,-4.05,;4.08,-4.05,;4.85,-2.71,;4.08,-1.38,)| Show InChI InChI=1S/C25H23ClFN7O4/c1-37-16-9-17(38-2)21(27)19(20(16)26)14-3-4-15(23-22(14)29-5-6-30-23)24(36)33-25-31-10-13(32-25)11-34-8-7-28-18(35)12-34/h3-6,9-10H,7-8,11-12H2,1-2H3,(H,28,35)(H2,31,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair