BDBM130365 US8822534, Example 11-1::US8822534, Example 12-1::US8993631, 9-1
SMILES: OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1
InChI Key: InChIKey=ZBGYPMPWJWNWEA-QGZVFWFLSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neutral endopeptidase (NEP) (Homo sapiens (Human)) | BDBM130365 (US8822534, Example 11-1 | US8822534, Example 12-1 ...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Novartis AG US Patent | Assay Description Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat... | US Patent US8822534 (2014) BindingDB Entry DOI: 10.7270/Q2513WW2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM130365 (US8822534, Example 11-1 | US8822534, Example 12-1 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte... | ACS Med Chem Lett 11: 188-194 (2020) Article DOI: 10.1021/acsmedchemlett.9b00578 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neutral endopeptidase (NEP) (Homo sapiens (Human)) | BDBM130365 (US8822534, Example 11-1 | US8822534, Example 12-1 ...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Novartis AG US Patent | Assay Description Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat... | US Patent US8993631 (2015) BindingDB Entry DOI: 10.7270/Q20C4THK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutral endopeptidase (NEP) (Homo sapiens (Human)) | BDBM130365 (US8822534, Example 11-1 | US8822534, Example 12-1 ...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Novartis AG US Patent | Assay Description Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat... | US Patent US8822534 (2014) BindingDB Entry DOI: 10.7270/Q2513WW2 | |||||||||||
More data for this Ligand-Target Pair |