BDBM1304 3-Aminopyridin-2(1H)-one analogue 24::5-ethyl-3-[(furan-2-ylmethyl)amino]-6-methyl-1,2-dihydropyridin-2-one::CHEMBL338129
SMILES: CCc1cc(NCc2ccco2)c(=O)[nH]c1C
InChI Key: InChIKey=ZBEYXZDTUARVJO-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1) | BDBM1304 (3-Aminopyridin-2(1H)-one analogue 24 | 5-ethyl-3-[...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HIV-1 reverse transcriptase (HIV-1 RT) | J Med Chem 39: 4065-72 (1996) Article DOI: 10.1021/jm960058h BindingDB Entry DOI: 10.7270/Q2Z039F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM1304 (3-Aminopyridin-2(1H)-one analogue 24 | 5-ethyl-3-[...) | PDB MMDB B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | 8.2 | n/a |
Merck Research Laboratories | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 35: 3792-802 (1992) Article DOI: 10.1021/jm00099a007 BindingDB Entry DOI: 10.7270/Q2GH9G3P | |||||||||||
More data for this Ligand-Target Pair |