BDBM13045 3-quinolinecarbonitrile analog 5::4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-{5-[(4-methylpiperazin-1-yl)methyl]-3-furyl}-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-{5-[(4-methylpiperazin-1-yl)methyl]furan-3-yl}quinoline-3-carbonitrile
SMILES: COc1cc(Nc2c(cnc3cc(ccc23)-c2coc(CN3CCN(C)CC3)c2)C#N)c(Cl)cc1Cl
InChI Key: InChIKey=MEBNSJCLFXPYII-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM13045 (3-quinolinecarbonitrile analog 5 | 4-[(2,4-Dichlor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Wyeth Research | Assay Description Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono... | J Med Chem 49: 7868-76 (2006) Article DOI: 10.1021/jm061031t BindingDB Entry DOI: 10.7270/Q28K779J | |||||||||||
More data for this Ligand-Target Pair |