BDBM130794 US8822448, 648

SMILES: COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C

InChI Key: InChIKey=HQWNFPJNIHUCAO-SFHVURJKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130794   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 9 (PDE9) (Rattus norvegicus (Rat))	BDBM130794 (US8822448, 648) Show SMILES COCCCN1CCN(C[C@@H]1C)C(=O)c1cc2c3n(CC4CCC4)ncc3c(=O)[nH]c2cc1C |r| Show InChI InChI=1S/C26H35N5O3/c1-17-12-23-21(24-22(25(32)28-23)14-27-31(24)16-19-6-4-7-19)13-20(17)26(33)30-10-9-29(18(2)15-30)8-5-11-34-3/h12-14,18-19H,4-11,15-16H2,1-3H3,(H,28,32)/t18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
					More data for this Ligand-Target Pair