BDBM130879 US8829199, 155

SMILES: CC(=O)N1CCN(Cc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1

InChI Key: InChIKey=GZRXWBJYUJUZNW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 130879   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM130879 (US8829199, 155) Show SMILES CC(=O)N1CCN(Cc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1 Show InChI InChI=1S/C27H28N8O2/c1-16-30-22-6-5-20(13-24(22)31-16)35-27(28)21(14-29-35)26(37)25-12-19-4-3-18(11-23(19)32-25)15-33-7-9-34(10-8-33)17(2)36/h3-6,11-14,32H,7-10,15,28H2,1-2H3,(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG US Patent					Assay Description The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...				US Patent US8829199 (2014) BindingDB Entry DOI: 10.7270/Q26T0KB8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM130879 (US8829199, 155) Show SMILES CC(=O)N1CCN(Cc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1 Show InChI InChI=1S/C27H28N8O2/c1-16-30-22-6-5-20(13-24(22)31-16)35-27(28)21(14-29-35)26(37)25-12-19-4-3-18(11-23(19)32-25)15-33-7-9-34(10-8-33)17(2)36/h3-6,11-14,32H,7-10,15,28H2,1-2H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG US Patent					Assay Description The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...				US Patent US8829199 (2014) BindingDB Entry DOI: 10.7270/Q26T0KB8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM130879 (US8829199, 155) Show SMILES CC(=O)N1CCN(Cc2ccc3cc([nH]c3c2)C(=O)c2cnn(c2N)-c2ccc3nc(C)nc3c2)CC1 Show InChI InChI=1S/C27H28N8O2/c1-16-30-22-6-5-20(13-24(22)31-16)35-27(28)21(14-29-35)26(37)25-12-19-4-3-18(11-23(19)32-25)15-33-7-9-34(10-8-33)17(2)36/h3-6,11-14,32H,7-10,15,28H2,1-2H3,(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG US Patent					Assay Description The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...				US Patent US8829199 (2014) BindingDB Entry DOI: 10.7270/Q26T0KB8
					More data for this Ligand-Target Pair