BDBM130929 US8829190, 107

SMILES: COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)n2nc(C)nc12

InChI Key: InChIKey=XCESBICUUKSBAJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130929   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM130929 (US8829190, 107) Show SMILES COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)n2nc(C)nc12 Show InChI InChI=1S/C15H12Cl2N4O2/c1-8-19-15-14(23-2)4-3-12(21(15)20-8)13(22)5-9-10(16)6-18-7-11(9)17/h3-4,6-7H,5H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human recombinant PDE4 (Gene bank accession no NM006203) was incubated for 1 hour with the test compound at concentrations up to 10 μM, with cAM...				US Patent US8829190 (2014) BindingDB Entry DOI: 10.7270/Q2Z89B3Z
					More data for this Ligand-Target Pair