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SMILES: COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)n2nc(nc12)C1(CC1)C(N)=O

InChI Key: InChIKey=RMUKYTGPHMFJTJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130940   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))		BDBM130940
PNG
(US8829190, 118)
Show SMILES COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)n2nc(nc12)C1(CC1)C(N)=O
Show InChI InChI=1S/C18H15Cl2N5O3/c1-28-14-3-2-12(13(26)6-9-10(19)7-22-8-11(9)20)25-15(14)23-17(24-25)18(4-5-18)16(21)27/h2-3,7-8H,4-6H2,1H3,(H2,21,27)
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MMDB

KEGG

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Similars
US Patent
n/an/a 3n/an/an/an/an/an/a



Leo Pharma A/S

US Patent


Assay Description
Human recombinant PDE4 (Gene bank accession no NM006203) was incubated for 1 hour with the test compound at concentrations up to 10 μM, with cAM...

US Patent US8829190 (2014)


BindingDB Entry DOI: 10.7270/Q2Z89B3Z
More data for this
Ligand-Target Pair