BDBM13095 CGS 27023A Analog 23::N-hydroxy-2-[(4-methoxybenzene)(2-phenylethyl)sulfonamido]acetamide
SMILES: COc1ccc(cc1)S(=O)(=O)N(CCc1ccccc1)CC(=O)NO
InChI Key: InChIKey=HYKIXGPXDGBTKU-UHFFFAOYSA-N
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Stromelysin-1 (Homo sapiens (Human)) | BDBM13095 (CGS 27023A Analog 23 | N-hydroxy-2-[(4-methoxybenz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 66 | -10.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Pharmaceuticals | Assay Description Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ... | J Med Chem 40: 2525-32 (1997) Article DOI: 10.1021/jm960871c BindingDB Entry DOI: 10.7270/Q2MW2FC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Meprin A subunit beta (Homo sapiens) | BDBM13095 (CGS 27023A Analog 23 | N-hydroxy-2-[(4-methoxybenz...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fraunhofer Institute for Cell Therapy and Immunology IZI Curated by ChEMBL | Assay Description Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay | Bioorg Med Chem Lett 27: 2428-2431 (2017) Article DOI: 10.1016/j.bmcl.2017.04.012 BindingDB Entry DOI: 10.7270/Q2CR5WH0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein 1 (Homo sapiens (Human)) | BDBM13095 (CGS 27023A Analog 23 | N-hydroxy-2-[(4-methoxybenz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
FibroGen Inc. Curated by ChEMBL | Assay Description Inhibition of PCP after 1 hr by fluorescence assay | Bioorg Med Chem Lett 22: 7397-401 (2012) Article DOI: 10.1016/j.bmcl.2012.10.067 BindingDB Entry DOI: 10.7270/Q22808SM | |||||||||||
More data for this Ligand-Target Pair |