BindingDB PrimarySearch

null

SMILES: Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1

InChI Key: InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N

PDB links: 21 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1086 hits for monomerid = 13216
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.0160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2020.112953 BindingDB Entry DOI: 10.7270/Q2KW5M3J
TBA					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...				Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	73	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...				Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	620	-8.46	n/a	n/a	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	2.60E+3	-7.61	n/a	n/a	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	2.70E+3	-7.59	n/a	n/a	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Time dependent inhibition of CYP3A4 in human liver microsomes				J Med Chem 55: 4896-933 (2012) Article DOI: 10.1021/jm300065h BindingDB Entry DOI: 10.7270/Q2PG1SVR
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Angiotensin-converting enzyme (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.15E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
E£tv£s Lor£nd University Curated by ChEMBL					Assay Description Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assay				J Med Chem 56: 8377-88 (2013) Article DOI: 10.1021/jm400813y BindingDB Entry DOI: 10.7270/Q2MG7SGG
E£tv£s Lor£nd University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2M32T55
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
eIF-2-alpha kinase GCN2 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	1.60E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q28W3BP9
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
Bristol-Myers Squibb Company					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [201-500] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	0.5	n/a	n/a	n/a	7.4	25
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,Q252H] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	1	n/a	n/a	n/a	7.4	25
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,Y253F] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	1	n/a	n/a	n/a	7.4	25
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,E255K] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	2	n/a	n/a	n/a	7.4	25
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,M351T] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	0.700	n/a	n/a	n/a	7.4	25
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,F359V] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	0.300	n/a	n/a	n/a	7.4	25
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,H396P] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,T315I] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [201-500,T315N] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Mast/stem cell growth factor receptor Kit [N822K] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [V559D] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [V559D,T670I] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
Ambit, Inc.					Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...				Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB
Ambit, Inc.					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	0.400	11	n/a	n/a	n/a	7.0	23
Chemical Genomics Centre of the Max Planck Society					Assay Description IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...				J Med Chem 52: 3915-26 (2009) Article DOI: 10.1021/jm9002928 BindingDB Entry DOI: 10.7270/Q2VT1QD3
Chemical Genomics Centre of the Max Planck Society					More data for this Ligand-Target Pair				3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src [251-533,T338M] (Gallus gallus (Chicken))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	7.0	23
Chemical Genomics Centre of the Max Planck Society					Assay Description IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...				J Med Chem 52: 3915-26 (2009) Article DOI: 10.1021/jm9002928 BindingDB Entry DOI: 10.7270/Q2VT1QD3
Chemical Genomics Centre of the Max Planck Society					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	n/a	590	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	n/a	0.690	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
Discoidin domain-containing receptor 2 [A642S] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	3.20	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Epidermal growth factor receptor [G719C] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	170	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Ephrin type-A receptor 3 [1-975] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	n/a	0.0900	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	0.580	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Ephrin type-B receptor 3 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	n/a	6.90	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	n/a	0.340	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src (Gallus gallus (Chicken))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	0.400	11	n/a	n/a	n/a	n/a	n/a
Chemical Genomics Centre of the Max Planck Society					Assay Description Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.				Nat Chem Biol 5: 394-6 (2009) Article DOI: 10.1038/nchembio.162 BindingDB Entry DOI: 10.7270/Q20V8B46
Chemical Genomics Centre of the Max Planck Society					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	495	n/a	n/a	n/a	n/a	n/a
Chemical Genomics Centre of the Max Planck Society					Assay Description Serine/threonine kinase inhibition assay using MAP p38 alpha fluorescence-labeled approach.				Nat Chem Biol 5: 394-6 (2009) Article DOI: 10.1038/nchembio.162 BindingDB Entry DOI: 10.7270/Q20V8B46
Chemical Genomics Centre of the Max Planck Society					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase FRK (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	0.310	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	8.10E+3	n/a	n/a	n/a	7.4	25
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2SX6BK3
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fgr (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2JD4V4C
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2DN43D1
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q25719CM
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q21G0JNW
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein-tyrosine kinase 6 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PCBioAssay	n/a	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2WQ026F
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2RX99G5
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TNNI3K (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2N58JRR
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 20 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2HD7T1F
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PCBioAssay	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2CN7293
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM13216 (BMS-354825 \| CHEMBL1421 \| DASATINIB \| N-(2-Chloro-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PCBioAssay	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a
Ambit Biosciences Curated by PubChem BioAssay					Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q28050ZJ
Ambit Biosciences Curated by PubChem BioAssay					More data for this Ligand-Target Pair				3D Structure (crystal)

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