BDBM13227 2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-isopropyl6-methylphenyl)-1,3-thiazole-5-carboxamide::BMS-354825 tert-Butoxycarbamate Analog 5h::CHEMBL336330::tert-butyl N-(4-methyl-5-{[2-methyl-6-(propan-2-yl)phenyl]carbamoyl}-1,3-thiazol-2-yl)carbamate

SMILES: CC(C)c1cccc(C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C

InChI Key: InChIKey=QQYIJVYKDGWWTP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 13227   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase LCK (Mus musculus)	BDBM13227 (2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...) Show SMILES CC(C)c1cccc(C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C Show InChI InChI=1S/C20H27N3O3S/c1-11(2)14-10-8-9-12(3)15(14)22-17(24)16-13(4)21-18(27-16)23-19(25)26-20(5,6)7/h8-11H,1-7H3,(H,22,24)(H,21,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of murine Lck kinase.				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair
Lck (Mus musculus)	BDBM13227 (2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...) Show SMILES CC(C)c1cccc(C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C Show InChI InChI=1S/C20H27N3O3S/c1-11(2)14-10-8-9-12(3)15(14)22-17(24)16-13(4)21-18(27-16)23-19(25)26-20(5,6)7/h8-11H,1-7H3,(H,22,24)(H,21,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.03E+4	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair