BDBM132297 US8841312, 40

SMILES: C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12

InChI Key: InChIKey=RXSMWEYGRAHVQN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 132297   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM132297 (US8841312, 40) Show SMILES C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 |THB:7:6:0.1:3| Show InChI InChI=1S/C26H29N7/c1-2-18-13-17(1)14-23(18)33-24-16-28-8-7-21(24)22-15-29-26(31-25(22)33)30-19-3-5-20(6-4-19)32-11-9-27-10-12-32/h3-8,15-18,23,27H,1-2,9-14H2,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM132297 (US8841312, 40) Show SMILES C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 |THB:7:6:0.1:3| Show InChI InChI=1S/C26H29N7/c1-2-18-13-17(1)14-23(18)33-24-16-28-8-7-21(24)22-15-29-26(31-25(22)33)30-19-3-5-20(6-4-19)32-11-9-27-10-12-32/h3-8,15-18,23,27H,1-2,9-14H2,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
					More data for this Ligand-Target Pair