BDBM132315 US8841312, 61

SMILES: C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1

InChI Key: InChIKey=CUXUPHRVKKHTFX-MRXNPFEDSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 132315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM132315 (US8841312, 61) Show SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 |r| Show InChI InChI=1S/C24H28N8/c1-16-15-31(11-10-26-16)18-6-7-22(27-12-18)29-24-28-13-20-19-8-9-25-14-21(19)32(23(20)30-24)17-4-2-3-5-17/h6-9,12-14,16-17,26H,2-5,10-11,15H2,1H3,(H,27,28,29,30)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
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