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BDBM13240 2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide::4-methyl-2-[(methylcarbamoyl)amino]-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide::BMS-354825 2-Amino-4-methyl-thiazole Analog 8a::CHEMBL338159

SMILES: CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C

InChI Key: InChIKey=WNFQUYWUNGWFPL-UHFFFAOYSA-N

Data: 4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13240   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13240
PNG
(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)
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Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13240
PNG
(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)
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n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13240
PNG
(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13240
PNG
(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair