BDBM132459 US8841312, 208

SMILES: CC1(C)CCC(CC1)n1c2nc(Nc3ccc(cn3)N3CCNCC3)ncc2c2ccnc(O)c12

InChI Key: InChIKey=XIMWLMPVHGWMSI-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 132459   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM132459 (US8841312, 208) Show SMILES CC1(C)CCC(CC1)n1c2nc(Nc3ccc(cn3)N3CCNCC3)ncc2c2ccnc(O)c12 Show InChI InChI=1S/C26H32N8O/c1-26(2)8-5-17(6-9-26)34-22-19(7-10-28-24(22)35)20-16-30-25(32-23(20)34)31-21-4-3-18(15-29-21)33-13-11-27-12-14-33/h3-4,7,10,15-17,27H,5-6,8-9,11-14H2,1-2H3,(H,28,35)(H,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
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