BDBM132548 US8841312, 297

SMILES: OCCCNc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1

InChI Key: InChIKey=YTNZPCAMOLEZQS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 132548   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM132548 (US8841312, 297) Show SMILES OCCCNc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 Show InChI InChI=1S/C21H24N8O/c30-11-3-9-23-18-6-7-19(28-27-18)25-21-24-12-16-15-8-10-22-13-17(15)29(20(16)26-21)14-4-1-2-5-14/h6-8,10,12-14,30H,1-5,9,11H2,(H,23,27)(H,24,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM132548 (US8841312, 297) Show SMILES OCCCNc1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1 Show InChI InChI=1S/C21H24N8O/c30-11-3-9-23-18-6-7-19(28-27-18)25-21-24-12-16-15-8-10-22-13-17(15)29(20(16)26-21)14-4-1-2-5-14/h6-8,10,12-14,30H,1-5,9,11H2,(H,23,27)(H,24,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
					More data for this Ligand-Target Pair