BDBM13257 BMS-354825 2-Heteroarylamino-thiazole Analog 12b::CHEMBL189675::N-(2-Chloro-6-methylphenyl)-2-[(3-pyridinyl)amino]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-(pyridin-3-ylamino)-1,3-thiazole-5-carboxamide

SMILES: Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccnc2)s1

InChI Key: InChIKey=WCBCZRZYPOPLAQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13257   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13257 (BMS-354825 2-Heteroarylamino-thiazole Analog 12b |...) Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccnc2)s1 Show InChI InChI=1S/C16H13ClN4OS/c1-10-4-2-6-12(17)14(10)21-15(22)13-9-19-16(23-13)20-11-5-3-7-18-8-11/h2-9H,1H3,(H,19,20)(H,21,22)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair