BDBM13261 BMS-354825 2-Heteroarylamino-thiazole Analog 12f::N-(2-chloro-6-methylphenyl)-2-(pyridazin-3-ylamino)-1,3-thiazole-5-carboxamide

SMILES: Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccnn2)s1

InChI Key: InChIKey=KBGFRWYMCYUHGU-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13261 (BMS-354825 2-Heteroarylamino-thiazole Analog 12f |...) Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccnn2)s1 Show InChI InChI=1S/C15H12ClN5OS/c1-9-4-2-5-10(16)13(9)20-14(22)11-8-17-15(23-11)19-12-6-3-7-18-21-12/h2-8H,1H3,(H,20,22)(H,17,19,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair