BDBM13276 BMS-354825 2-Heteroarylamino-thiazole Analog 12u::N-(2-Chloro-6-methylphenyl)-2-(2-methyl-6-(3-morpholinopropyl)-pyrimidin-4-ylamino)-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-[(2-methyl-6-{[3-(morpholin-4-yl)propyl]amino}pyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide

SMILES: Cc1nc(NCCCN2CCOCC2)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1

InChI Key: InChIKey=CRHCQKSSAJEGRA-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13276 (BMS-354825 2-Heteroarylamino-thiazole Analog 12u |...) Show SMILES Cc1nc(NCCCN2CCOCC2)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1 Show InChI InChI=1S/C23H28ClN7O2S/c1-15-5-3-6-17(24)21(15)30-22(32)18-14-26-23(34-18)29-20-13-19(27-16(2)28-20)25-7-4-8-31-9-11-33-12-10-31/h3,5-6,13-14H,4,7-12H2,1-2H3,(H,30,32)(H2,25,26,27,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair