BDBM13277 BMS-354825 2-Heteroarylamino-thiazole Analog 12v::N-(2-Chloro-6-methylphenyl)-2-(6-(2-hydroxyethylamino)-2-methylpyrimidin-4-ylamino)-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[(2-hydroxyethyl)amino]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide

SMILES: Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(NCCO)nc(C)n2)s1

InChI Key: InChIKey=UZKWSGJDJDMOGQ-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13277 (BMS-354825 2-Heteroarylamino-thiazole Analog 12v |...) Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(NCCO)nc(C)n2)s1 Show InChI InChI=1S/C18H19ClN6O2S/c1-10-4-3-5-12(19)16(10)25-17(27)13-9-21-18(28-13)24-15-8-14(20-6-7-26)22-11(2)23-15/h3-5,8-9,26H,6-7H2,1-2H3,(H,25,27)(H2,20,21,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair